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Acute Lymphocytic Leukemia

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发表于 12-26-2017 17:47:16 | 显示全部楼层 |阅读模式
Leslie Gauthier, Carolers Are Shooed Away, But a Love Stay; As Christmas nears, a woman with pediatric leukemia basks in a new romance. New York Times, Dec 24, 2017 (in the weekly column Modern Love).
https://www.nytimes.com/2017/12/ ... arols-leukemia.html

Bote:
(a) Pediatric leukemia is not a medical term.
(i) This Too Shall Pass: Survivor Guilt. Giving, Memorial Sloan-Kettering Cancer Center, undated
https://giving.mskcc.org/too-shall-pass-survivor-guilt
("Leslie Gauthier, who was diagnosed with an aggressive T cell lymphoblastic leukemia in November 2011, just a few months after graduating from college. * * * Leslie, who is now cancer free")
(ii) It was ALL: acute lymphocytic leukemia or acute lymphoblastic leukemia.
(iii)
(A) How Is Acute Lymphocytic Leukemia Classified?  American Cancer Society, Last Revised: Feb 18, 2016
https://www.cancer.org/cancer/ac ... ow-classified.html. Cancer
("Most types of cancers are assigned numbered stages to describe their extent in the body, based on the size of the tumor and how far the cancer has spread.  Acute lymphocytic leukemia (ALL), on the other hand, does not usually form tumor masses. It generally affects all of the bone marrow in the body and, in many cases, might have spread to other organs, such as the liver, spleen, and lymph nodes. Therefore the outlook for the patient with ALL depends on other information, such as the subtype of ALL (determined by lab tests), the age of the patient, and other lab test results. * * * In general, T-cell ALL has a better prognosis")
(B) "The risk for developing ALL is highest in children younger than 5 years of age. The risk then declines slowly until the mid-20s, and begins to rise again slowly after age 50. Overall, about 4 of every 10 cases of ALL are in adults."  American Cancer Society, Last Revised: Jan 5, 2017.
(iv) Hossain MJ et al, Characterization of Pediatric Acute Lymphoblastic Leukemia Survival Patterns by Age at Diagnosis. J Cancer Epidemiol, (2014)
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4182848/
("There was significant variability in pediatric ALL survival by age at diagnosis. Survival peaked among children diagnosed at 1–4 years and steadily declined among those diagnosed at older ages. Infants (<1 year) had the lowest survivorship. In a multivariable Cox proportional hazard model stratified by year of diagnosis, those diagnosed in age groups 1–4, 5–9, 10–14, and 15–19 years were 82%, 75%, 57%, and 32% less likely to die compared to children diagnosed in infancy, respectively. Age at diagnosis remained to be a crucial determinant of the survival variability of pediatric ALL patients, after adjusting for sex, race, radiation therapy, primary tumor sites, immunophenotype, and year of diagnosis [1973-2009]")

(b) Memorial Sloan Kettering Cancer Center
https://en.wikipedia.org/wiki/Me ... ering_Cancer_Center
(1884- ; Affiliated with Cornell)
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